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Clinical Question
Do Atorvastatin and Rosuvastatin improves serum lipid levels if be given
every other day?
Bottom Line
Every other day treatment with long-acting statins significantly improves
serum lipid levels.
Reference
Decreasing LDL Cholesterol and Medication Cost With Every-Other-Day Statin
Therapy.Juszczyk MA, Seip RL, Thompson PD.Prev Cardiol. 2005
Fall;8(4):197-9.
Synopsis
Statins are administered daily, but because of their long half-lives,
atorvastatin and rosuvastatin can be given every other day (q.o.d.). We
examined the effect of q.o.d. statin therapy in 25 patients treated with
either atorvastatin (mean dose, 18.8 mg q.o.d.) or rosuvastatin (mean dose,
9.7 mg q.o.d.). Low-density lipoprotein cholesterol decreased 43%,
triglycerides (mean +/- SEM) decreased 22%+/-6%, and high-density
lipoprotein cholesterol increased 9%+/-6% with q.o.d. atorvastatin (n=9;
p<0.05 for all). Low-density lipoprotein cholesterol decreased 28%,
triglycerides decreased 15%+/-6%, and high-density lipoprotein cholesterol
increased 10%+/-5% with rosuvastatin q.o.d. (n=16; p<0.05 for all). |