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BACKGROUND:
Physical activity may play a role in preventing gallstone disease.
METHODS:
The activity/gallstone relationship was examined in post-menopausal women
from the Study of Osteoporotic Fractures (SOF; 1986-1988), a prospective
study of fracture risk factors in 8010 women (mean age = 71.1 years, SD =
4.9).
RESULTS:
Multivariate logistic regression indicated women in the lowest two quartiles
of physical activity, according to questionnaire, had a 59% {OR = 1.59
(1.11-2.29), P = 0.02} and a 57% higher risk {OR = 1.57 (1.11-2.23), P =
0.01} of developing gallstone disease compared to women in the highest
quartile of activity (PTrend = <0.0001). Additionally, this relationship was
examined in a cohort of 182 post-menopausal women (mean age 74.2 years, SD =
4.1) who participated in a randomized controlled trial of a walking
intervention. Women in the randomized clinical trial in the lowest tertile
of physical activity determined by a physical activity monitor had a higher
risk of developing gallstone disease than women in the highest tertile of
physical activity, 13% {OR-1.13 (1.01-1.28), P = 0.05, PTrend = <0.04}.
CONCLUSION:
Physical activity appears to be inversely related to the development of
gallstone disease in post-menopausal women independent of body mass index.
Reference:
Prev Med. 2005 Sep-Oct;41(3-4):772-7 |