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Online Clinical Calculator |
The best time to administer
anti-cholesterol agents
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Clinical Question:
What is the best time to take in anti-cholesterol agents in patients with
hyperlipidemia?
Bottom Line:
Changes in the levels of total cholesterol, low-density-lipoprotein
cholesterol, triglycerides, and high-density-lipoprotein cholesterol were
similar among hyperlipidemic patients receiving atorvastatin calcium 40 mg,
regardless of the time of day the drug was administered.
Reference:
Effects of morning versus evening administration of atorvastatin in patients
with hyperlipidemia.Plakogiannis R, Cohen H, Taft D.
Synopsis:
The effects of morning versus evening administration of atorvastatin in
hyperlipidemic patients were studied. Patients whose care was managed by a
teaching hospital run by the Department of Veterans Affairs who were
prescribed atorvastatin calcium 40 mg p.o. daily by their primary care
physician were interviewed by a clinical pharmacist in the ambulatory care
clinic for study enrollment. Patients were excluded if they had diseases or
conditions or took medication known to affect serum lipoprotein levels, as
were patients who consumed more than three alcoholic drinks per day and
those who could not verify the time of atorvastatin administration. Blood
samples were collected after a 12-hour fasting period and serum lipoprotein
levels were measured at baseline and after four weeks. Of the 204
hyperlipidemic patients receiving atorvastatin, 64 met the inclusion
criteria and were enrolled in the study, 32 of whom took the drug in the
morning (before noon) and an equal number who took the drug at night (after
6 p.m. but before midnight). All patients were male outpatients with a mean
+/- S.D. age of 57.8 +/- 7.8 years and 58.5 +/- 7.8 years for the morning
and evening administration groups, respectively. No statistically
significant differences in lipid values measured were found between the
morning and evening administration group after four weeks.
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